Managed to get to floor 35 with some nice archery stuff where I died unceremoniously to the last enemy before the magma core boss (ran out of energy consumables). Mouse wood scales incredibly well with extra energy, so I would just burst down every enemy/boss on turn 1 using the emerald necklaces and avoid having to block entirely.
On a sadder note, save functionality is entirely broken for me, so I've basically stopped playing for now. Long Endless runs can take me hours so not being able to take a break and load saves later is too punishing. Can't even visit Matthew anymore. :'(
Love this game though! Can't wait for it to be downloadable and excited for extra difficultly levels.